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Contemplate alternant therapies that are not moderate CYP3A inducers throughout therapy with mitapivat. If unable to avoid coadministration, monitor Hb and titrate over and above 50 mg BID, if necessary, but do not exceed mitapivat dose of a hundred mg BID. .pentobarbital will lessen the extent or influence of armodafinil by impacting hepatic/intes